QUALIA LIFE

SUPPORTS CELL ENERGY FOR BETTER AGING

897 AED

QUALIA LIFE IS DESIGNED TO:

Amplify Productivity

Promote Restful Sleep

Upgrade Energy Levels

Support Mitochondrial Fitness & Cell Energy

Promote NAD+ & ATP

Provide Support for Handling Stress

LEARN MORE ABOUT THE INGREDIENTS

SENSORIL® ASHWAGANDHA WITHANIA SOMNIFERA ROOT AND LEAF EXTRACT

TOP BENEFITS OF WITHANIA SOMNIFERA

  • Supports healthy aging
  • Supports energy
  • Supports a healthy stress response
  • Supports exercise performance
  • Supports healthy weight
  • Supports healthy metabolism
  • Supports mitochondrial structure and function
  • Supports antioxidant defenses
  • Supports brain function and mental cognition
  • Supports thyroid function
  • Supports healthy joint function
  • Supports blood sugar balance
  • Supports sleep

WHAT IS WITHANIA SOMNIFERA?

Ashwagandha is an Ayurvedic herb with adaptogenic properties—it’s often referred to as “Indian ginseng.” Ashwagandha has a long history of use and has been reported to have several health-promoting effects, supporting healthy energy, metabolism, stress response, physical performance, sleep, joint health, and cognitive performance. The novel active constituents are a group of plant compounds called withanolide glycosides. Sensoril® root and leaf extract is standardized for withanolide glycoside content.

NEUROHACKER’S WITHANIA SOMNIFERA SOURCING

Sensoril® has been clinically tested in 10 randomized, double-blind, placebo-controlled human trials.

Created by Natreon Inc., a leader in scientifically studied and tested Ayurvedic ingredients.

Leaf and root extract triple standardized to contain a minimum of 10% withanolide glycosides, the main bioactive; a minimum of 32% oligosaccharides, which increase the bioavailability of the withanolide glycosides; and a maximum of 0.5% free withanolides (as Withaferin A).

Protected by multiple U.S. patents with self-affirmed generally recognized as safe (GRAS) status).

Vegetarian ● Organic compliant or certified organic ● Non-GMO Allergen & Gluten-free ● Kosher & Halal certified

WITHANIA SOMNIFERA DOSING PRINCIPLES AND RATIONALE

We consider Ashwagandha to be an herbal adaptogen, so expect it to follow hormetic dosing principles (see Neurohacker Dosing Principles). Herbal adaptogens tend to have a hormetic zone (or range) where there’s a favorable biological response. It’s important to be in this zone; it’s just as important not to be above it. So, it’s important to identify the lowest dose that can produce the desired response. Sensoril®—the standardized extract we use—produced a threshold  response in a study that gave different daily dosages—125 mg, 250 mg, 500 mg. Effect size was slightly greater for the higher doses, but most of the change was evident with the lowest dose. 1 We opted for this lower dose to be consistent with a core hormetic principle—only do or use as much as something as would be needed to stimulate the desired response.

WITHANIA SOMNIFERA KEY MECHANISMS

Mitochondrial structure and function

  • Supports mitochondrial membrane potential and structural integrity
  • Protects from mitochondrial damage
  • Protects from mitochondrial membrane permeabilization
  • Protects from complex I-V Inhibition (protects electron transport chain and oxidative phosphorylation performance)
  • Upregulates citric acid cycle enzymes

Improves exercise performance (ergogenic effect)

  • Supports endurance performance
  • Supports muscle strength
  • Supports post-exercise recovery

Metabolism

  • Supports healthy insulin sensitivity
  • Supports healthy blood glucose levels
  • Supports healthy leptin signaling

Body weight 

  • Supports healthy body weight
  • Supports healthy feeding behaviors
  • Upregulates lean mass

Antioxidant defenses

  • Upregulates antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx])
  • Replenishes glutathione (GSH) levels
  • Downregulates oxidative stress and reactive oxygen species levels

Cellular signaling 

  • Downregulates the expression of proinflammatory cytokines – tumor necrosis factor alpha (TNFα), interleukin 1 beta (IL-1β), and IL-6

Brain function

  • Supports cognitive and psychomotor performance
  • Supports memory, executive function, attention, and information processing speed
  • Neuroprotective – protects from neuronal mitochondrial swelling and apoptosis; protects cognitive function (ischemia, oxidative stress)
  • Protects from neurotoxicity
  • Downregulates the basal activity levels of acetylcholine esterase
  • Upregulates dopamine levels
  • Supports mood
  • Regulates neural cytokine signaling
  • Supports quality of sleep

Thyroid function

  • Supports thyroid function

Stress response

  • Supports stress management
  • Downregulates serum cortisol levels
  • Downregulates endoplasmic reticulum (ER) stress

Healthy aging and longevity 

  • Lifespan extension effects (Caenorhabditis elegans)
  • Upregulates insulin-like growth factor-1 (IGF-1) signaling pathway
  • Downregulates α-synuclein and amyloid-β aggregation
  • Upregulates FOXO3A and SIRT3

BIOVIN FRENCH RED GRAPES EXTRACT

TOP BENEFITS OF BIOVIN

  • Supports healthy aging
  • Supports exercise performance
  • Supports metabolic heath and healthy weight
  • Supports mitochondrial health
  • Supports cellular responses and antioxidant defenses
  • Support cardiovascular function
  • Supports brain function
  • Supports healthy gut microbiota

WHAT IS BIOVIN?

BioVin® is made from the juice, seeds, and skins of French red grapes. It provides a full spectrum of grape’s health-promoting compounds. Grape skins and seeds contain small amount of trans-resveratrol. This compound has been the subject of hundreds or pre-clinical and clinical research studies. While trans-resveratrol has received a great deal of research attention, grapes are more than one compound: They contain resveratrol derivatives (e.g., viniferins, polydatin) and polyphenol compounds (e.g., oligomeric proanthocyanidins, quercetin, gallic acids, catechins). These compounds have synergies with trans-resveratrol. We think it makes sense to use a full spectrum extract to capture these synergies.

NEUROHACKER’S BIOVIN® SOURCING

BioVin is a full spectrum French red grape extract. Made from grape juice, seeds, and skins of Vitis vinifera, whole red grapes from Rhone Valley, Southern France.

Standardized to contain 5% trans-resveratrol and not less than 40% grape oligomeric proanthocyanidins.

Non-GMO, Vegan

BIOVIN DOSING PRINCIPLES AND RATIONALE

When thinking about the dose of BioVin there’s a few things to keep in mind. This grape extract has been standardized to contain 5% trans-resveratrol and not less than 40% oligomeric proanthocyanidins. The extract also has other compounds that naturally occur in grape juice, seeds, and skin. While trans-resveratrol is one of the reasons we use this extract, it’s the synergy of all of grape’s phytonutrients that is the story. Focusing only on the trans-resveratrol content misses the big picture. That said, we don’t view trans-resveratrol as a more is better compound. It might be better thought of as a hormetic substance; something that in low to moderate amounts helps promote an adaptive response to stress, but which doesn’t work as well at very high doses. Our goal with trans-resveratrol, as with all many ingredient choices, is to select the lowest dose needed to produce desired benefits, especially in the context of other ingredient synergies. Studies have used resveratrol alone in doses as low as 10 mg … and doses of several grams. When used as part of a grape extract, the amount of resveratrol in the study has typically been less than 10 mg. When we choose our BioVin® dose the goal was to be at or above the low-dose resveratrol threshold, which we think of as being 10 mg. This allows us to also provide a meaningful dose of 80 mg per serving of oligomeric proanthocyanidins.

BIOVIN KEY MECHANISMS

Grape proanthocyanidins

Mitochondrial biogenesis

  • Upregulates peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1α)
  • Upregulates nuclear transcription factors of mitochondrial biogenesis (nuclear respiratory factor-1 [NRF-1], NRF-2, mitochondrial transcription factor A [TFAM]

Mitochondrial structure and function

  • Supports mitochondrial DNA (mtDNA)
  • Protects mitochondrial structure
  • Protects from complex I-V inhibition
  • Supports the activities of TCA cycle enzymes
  • Supports β-oxidation
  • Upregulates the NAD+ pool

Signaling pathways

  • Upregulates AMPK signaling

Antioxidant defenses

  • Downregulates reactive oxygen species (ROS) levels and oxidative stress
  • Upregulates antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx])

Cellular signaling

  • Downregulates the expression of proinflammatory cytokines (tumor necrosis factor alpha [TNFα], interleukin-6 [I-6], nuclear factor kappa B [NF-κB])

Metabolism

  • Supports healthy insulin sensitivity
  • Upregulates the insulin signaling pathway
  • Upregulates the glucose transporter GLUT4

Body weight

  • Downregulates fat accumulation and blood/liver lipid levels

Exercise performance

  • Supports endurance performance

Cardiovascular function

  • Supports healthy blood pressure
  • Supports vasodilation

Gut microbiota

  • Regulates the composition of the gut microbiota
  • Supports gut barrier function
  • Regulates gut oxidative stress

Healthy aging and longevity 

  • Upregulates SIRT-1
  • Downregulates mTOR signaling
  • Upregulates UCP-1
  • Extends lifespan (Drosophila melanogaster)

Other

  • Protects liver structure and function
  • Modulates the gut microbiota composition
  • Modulates circadian rhythms

Synergies

  • Gynostemma pentaphyllum (in improving insulin sensitivity)

Resveratrol

Mitochondrial biogenesis

  • Upregulates peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1α)
  • Upregulates nuclear transcriptional factors of mitochondrial biogenesis (nuclear respiratory factor-1 [NRF-1], NRF-2, mitochondrial transcription factor A [TFAM])

Mitochondrial structure and function

  • Upregulates mitochondrial size and number
  • Upregulates inner mitochondrial membrane folding (cristae)
  • Upregulates mitochondrial DNA (mtDNA)
  • Supports mitochondrial membrane potential
  • Upregulates citrate synthase
  • Upregulates ATP production
  • Upregulates NAD+ pool
  • Upregulates components of the electron transport chain – complex I-V [38]
  • Supports β-oxidationSignaling pathways
  • Upregulates AMPK signaling
  • Upregulates liver kinase B1 (LKB1) signaling
  • Upregulates peroxisome proliferator-activated receptor alpha (PPARα)
  • Downregulates peroxisome proliferator-activated receptor gamma (PPARγ)
  • Upregulates estrogen-related receptor alpha (ERR α)Upregulates forkhead transcription factor O 1 (FOXO1)
  • Inhibits phosphodiesterase (PDE) 1 and 4  and activates adenylate cyclase  – upregulates cAMP levels

Antioxidant defenses

  • Downregulates reactive oxygen species (ROS) levels and oxidative stress
  • Upregulates antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx])
  • Downregulates pro-oxidant enzymes (NADPH oxidase)

Insulin signaling

  • Supports healthy insulin sensitivity

Body weight

  • Downregulates fat accumulation and blood/liver lipid levels
  • Supports thermogenesis
  • Upregulates adiponectin levels

Cardiovascular function

  • Supports healthy vascular function
  • Protects cardiac function

Brain function

  • Supports cerebral blood flow
  • Neuroprotective against neurotoxic agents

Exercise performance

  • Supports endurance performance
  • Supports muscle structure and function
  • Supports glucose uptake in muscles

Gut microbiota

  • Regulates the composition of the gut microbiota
  • Regulates gut microbial metabolism
  • Modulates gut microbial gene expression
  • Supports gut barrier function
  • Regulates gut cytokine signaling

Healthy aging and longevity 

  • Upregulates SIRT1
  • Upregulates mitochondrial uncoupling proteins UCP1, UCP2, and UCP3
  • Upregulates Klotho
  • Downregulates mTOR signalin
  • Delays age-related physiological changes 
  • Extends lifespan (mice on high-calorie diet, Drosophila melanogaster, Caenorhabditis elegans, Saccharomyces cerevisiae)

Synergies

  • Apigenin
  • Piperine

L-TRYPTOPHAN

TOP BENEFITS OF L-TRYPTOPHAN

  • Supports cell energy generation
  • Supports healthy aging
  • Supports healthy sleep and body clock function
  • Supports prosocial behaviors

WHAT IS L-TRYPTOPHAN?

L-Tryptophan is an essential amino acid. The body cannot synthesize it: it must be obtained from the diet. It functions as a metabolic precursor (i.e., substrate) for the synthesis of nicotinamide adenine dinucleotide (NAD), an important coenzyme found in all living cells—NAD is used for mitochondrial energy production and activation of the important sirtuin healthspan pathways. NAD can be made by any molecule which contains a niacin or nicotinamide (vitamin B3) molecule. L-Tryptophan is unique because it’s the only other way to build NAD that doesn’t start from vitamin B3. L-Tryptophan is also the precursor for the synthesis of the neurotransmitter serotonin and the neurohormone melatonin, which regulates sleep-wake cycles and nighttime body clock functions. In addition to these three main molecules, L-tryptophan is involved in making many other important intermediate molecules. Giving extra L-tryptophan allows the body to use it where it is needed most … at that time and over the next 12-16 hours. In general, giving extra L-tryptophan with breakfast supports both daytime mood (presumably via supporting serotonin function) and nightly sleep (presumably via supporting melatonin function). Giving some extra L-tryptophan also helps support body clock, orienting many of it’s daytime functions earlier in the day. L-tryptophan supplementation may support prosocial behaviors. Low-to-modest doses of L-tryptophan prior to bed may support healthier sleep cycles.

NEUROHACKER’S L-TRYPTOPHAN SOURCING

L-Tryptophan is used as a precursor (i.e., substrate) by the body to make NAD, serotonin, and melatonin. Our main reason for including it in a formulation would be to support biosynthesis of one or more of these important molecules.

In general, L-tryptophan is additive with other strategies for making NAD (such as the non-flushing form (niacinamide) and flushing form (niacin) of vitamin B3, so it can be useful to stack the two together in formulations.

L-Tryptophan sourcing is focused on identifying and purchasing from a reputable supplier and ensuring it is NON-GMO, gluten-free and vegan.

L-TRYPTOPHAN DOSING PRINCIPLES AND RATIONALE

L-Tryptophan is generally considered to be dose-dependent in the range it’s commonly dosed (between several hundred mg to several grams or more a day). It’s been estimated that an average adult diet provides about 800-1000 mg/day of L-tryptophan. In studies that have looked at augmenting the breakfast meal with L-tryptophan, amounts less than the amount in an average diet have been sufficient to produce positive subjective responses during the day, with sleep that night, and with overall body clock function. When taken prior to bed, a dose close to ¼ the daily average intake has been sufficient to support healthier deep sleep. These studies are consistent with L-tryptophan supplementation supporting healthier function when given in amounts that are less than what would be found in an average diet.

L-TRYPTOPHAN KEY MECHANISMS

NAD(P) synthesis

  • L-tryptophan is a substrate in the de novo NAD+ synthesis pathway via the kynurenine pathway (KP)
  • NAD+ can be converted to the coenzyme NADP+ by the enzyme NAD kinase
  • NAD(H) and NADP(H) are key molecules in essential redox pathways of cellular metabolism and energy production
  • NAD(H) is essential for the production of ATP through the citric acid cycle and oxidative phosphorylation
  • NADP(H) is essential in many anabolic metabolic reactions, including DNA and RNA synthesis
  • NADP(H) is a cofactor for some cytochrome P450 enzymes that detoxify xenobiotics
  • NADPH also acts as a cofactor for glutathione reductase, the enzyme used to maintain reduced glutathione (GSH) levels
  • NAD(H) and NADP(H) are essential for healthy aging

Brain function

  • L-tryptophan is a precursor for serotonin (a neurotransmitter) and melatonin (a neurohormone) synthesis
  • Upregulates the rate of serotonin synthesis
  • Promotes social behavior

Exercise performance (ergogenic effect)

  • Supports power output
  • Delays time to exertion

Social Cognition

  • Supports healthier social interactions
  • Promotes charitable behaviors

Synergies

  • Nicotinic acid (niacin) and nicotinamide (niacinamide) as substrates for NAD synthesis.

POLYPHENOLS

WHAT ARE POLYPHENOLS?

Dietary polyphenols are a family of plant compounds found in common foods including fruits, vegetables, nuts, chocolate, coffee, and tea. These compounds play important roles in the plant kingdom, protecting plants from infections, pests, UV irradiation from the sun, oxidative stress, and toxic metals and chemicals. They also act as signaling molecules used for processes like growth and ripening. More than 8000 different polyphenols have been identified in plants; over half are flavonoids, the plant compounds responsible for the bright colors in fruits and vegetables. Many polyphenol compounds, resveratrol as an example, increase when a plant is injured or stressed and are part of the plant’s adaptive response to the environment.

BENEFITS OF POLYPHENOLS

Eating these compounds seems to provoke an adaptive response in humans and animals, shifting gene expression in numerous molecules and pathways in ways that confer a degree of stress resistance and cellular protection. Some experts believe that polyphenols are an example of hormesis; similar to exercise they act as a mild stress and result in positive adaptations. Other experts have proposed that they act by xenohormesis, serving as benign cues that inform us about the types of stress plant’s are experiencing, which allows our cells to anticipate the future. Eating a diet rich in polyphenols is part of an overall healthspan strategy. Higher dietary intake of polyphenols has been associated with increased longevity and better health.

NEUROHACKER’S POLYPHENOL SOURCING

Many of the plant ingredients we included—apple, black ginger, citrus, cocoa, and grape extracts—are standardized for unique polyphenols. Collectively, they provide a variety of polyphenol compounds. In general, polyphenols tend to produce threshold or hormetic responses, so are more of a “just right amount” than a “more is better” ingredient. They also should be considered in combination rather than in isolation. In other words, the cumulative amount from all the ingredients should be considered and compared to a studied does of a single molecule in isolation. Even this would underestimate dose, because polyphenols are thought to be more than additive … having synergistic or amplifying effects when dosed in combinations.

UBIQUINONE (COENZYME Q10)

TOP BENEFITS OF COQ10

  • Supports mitochondrial health
  • Supports antioxidant defenses
  • Support cardiovascular function
  • Supports brain function
  • Supports healthy aging

WHAT IS COQ10?

Coenzyme Q10 (CoQ10) is an important fat-soluble nutrient, because it’s essential for cellular energy production (i.e., ATP) and antioxidant defenses, helping protect membranes from oxidative stress. Because of its central role in ATP generation, the highest amounts of CoQ10 are found in organs that use the most energy, like the heart, liver, and kidneys. Meat and fish, especially their organs, are very good food sources. The best vegetarian sources are foods high in fat, including nuts, seeds, avocados, and vegetable oils. A person eating an average diet will get about 3-6 mg of CoQ10 a day. Most CoQ10 isn’t from diet, it’s made in the body (i.e., biosynthesized), with creation requiring at least 12 genes. While the human body can make CoQ10, it may not always be able to make enough to meet its needs. This seems to occur with aging, because CoQ10 gradually declines with age in a number of different tissues.

NEUROHACKER’S COQ10 SOURCING

CoQ10 is most commonly supplemented in its oxidized from, which is called ubiquinone. Most human clinical studies has been the ubiquinone form. It can also be supplemented in its reduced ubiquinol form.

CoQ10 sourcing is focused on ensuring it is non-GMO, gluten-free and vegan.

COQ10  DOSING PRINCIPLES AND RATIONALE

CoQ10 is dose-dependent in the range it’s commonly dosed (30 mg to several hundred milligrams a day). Body stores are maintained by a combination of the CoQ10 we consume in foods and supplements, and the CoQ10 made in our body.(7) It’s been suggested that a daily intake ranging from 30–100 mg in otherwise healthy persons is a good range to maintain healthy levels. CoQ10 is additive with other mitochondrial and antioxidant nutrients. This means lower doses of CoQ10 are often needed to support healthy function when it is combined with other nutrients, compared to when it is given as an isolated nutrient.

COQ10 KEY MECHANISMS

Mitochondrial biogenesis

  • Upregulates peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC1α)
  • Upregulates nuclear transcription factors of mitochondrial biogenesis (nuclear respiratory factor 2 [NRF2], mitochondrial transcription factor A [TFAM])
  • Upregulates mitochondrial DNA (mtDNA)
  • Upregulates mitochondrial number

Mitochondrial function

  • CoQ10 is part of the electron transport chain of the inner mitochondrial membrane
  • CoQ10 transfers electrons from complexes I and II to complex III by undergoing redox cycles between its three redox states (ubiquinone [fully oxidized], ubisemiquinone, and ubiquinol [fully reduced])
  • CoQ10 is critical in ATP generation via the electron transfer chain
  • Supports mitochondrial complex I-V performance
  • Promotes ATP production
  • Upregulates the NAD+ pool (NAD/NADH ratio)
  • Supports β-oxidation
  • Downregulates NAD(P)H:quinone oxidoreductase 1 (NQO1) (upregulated in response to mitochondrial impairment to protect the cells against oxidative stress)

Mitochondrial structure

  • Supports mitochondrial membrane potential

Signaling pathways

  • Upregulates AMP-activated protein kinase (AMPK) activity
  • Upregulates peroxisome proliferator-activated receptor alpha (PPARα)
  • Upregulates liver kinase B1 (LKB1)
  • Upregulates cAMP

Lysosomal function

  • Supports the transport of protons across lysosomal membranes to maintain the optimal pH
  • Supports the activity of digestive enzymes within lysosomes
  • Supports the lysosomal digestion of cellular debris

Antioxidant defenses

  • Coenzyme Q10 (as ubiquinol) is a potent lipid soluble antioxidant
  • Protects from the peroxidation of cell membrane lipids and of lipoproteins in the blood
  • Protects from oxidative damage of proteins, lipids, and DNA
  • Downregulates the production of reactive oxygen species (ROS)
  • Upregulates antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx])
  • Replenishes glutathione (GSH) levels
  • Regenerates the lipophilic antioxidant alpha-tocopherol (vitamin E)

Body weight

  • Downregulates fat accumulation and blood/liver lipid levels
  • Inhibits adipocyte differentiation and lipid accumulation
  • Downregulates peroxisome proliferator-activated receptor gamma (PPARγ)
  • Promotes the thermogenic function of brown adipose tissue (BAT)
  • Upregulates uncoupling protein 1 (UCP1)

Cardiovascular function

  • Cardioprotective effects
  • Protects vascular function
  • Protects endothelial cells against oxidative damage
  • Protects endothelial progenitor cells
  • Supports endothelial function and blood flow

Brain function

  • Neuroprotective against neurotoxic agents 
  • Upregulates the number of mitochondria in the brain

Healthy aging and longevity

  • Upregulates SIRT1 and SIRT3
  • Protects from DNA double-strand breaks
  • Extends lifespan (rats fed on a PUFA-rich diet)

Synergies

  • Lipoic acid — support of mitochondrial function
  • Creatine — neuroprotection and support of mitochondrial function
  • L-carnitine  — support of mitochondrial function
  • Piperine — increases bioavailability of CoQ10
  • Vitamin B3 (NAD+ precursors)  — supports improved mitochondrial performance
  • Vitamin E — support of mitochondrial function

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